Company:
Belharra Therapeutics, Inc.
Location: San Diego
Closing Date: 25/10/2024
Salary: £125 - £150 Per Annum
Hours: Full Time
Type: Permanent
Job Requirements / Description
WHAT WE ARE LOOKING FOR
Belharra is looking for a motivated Scientist I/II to join our proteomics team. In this role, you’ll collaborate with chemists and biologists to create and use specialized tools for drug discovery. The successful candidate will have a background in high-throughput sample preparation and small molecule screening of large libraries. We are seeking a self-starter with strong problem-solving skills and an innovative mindset. This role will contribute to the growth of Belharra’s research portfolio by screening high value targets in a variety of cell-based assays.
WHAT YOU’LL BE RESPONSIBLE FOR
- Align with proteomics team to develop and advance an in-cell proteomic platform to profile proteome wide engagement of chemical probes though quantitative mass spectrometry.
- The candidate will work closely within the proteomics team identify and characterize hits from our chemoproteomics platform.
- Align with and support the platform group for different types of mass sample preparations including probe enrichments, competition, and dose response analysis.
- Support biology group with chemical probe validation of screening hits and confirming target engagement and selectivity.
- Interface with chemistry group to advance understanding of structure-activity relationships and in cell target engagement.
- Participate in all aspects of laboratory operations.
- Candidate must have excellent problem-solving skills and be self-motivated.
- Strong ability to communicate with project teams through presentations.
- Clearly and accurately document work.
- Perform under tight timelines and work effectively across multiple projects and align with different project teams.
Requirements
- PhD or MS with 8+ years or BS with 10+ years.
- Chemical biology experience including mechanism of action studies and probe profiling, biochemistry, cell biology, and quantitative mass spectrometry methods desired (industry experience preferred).
- Ability to work closely across disciplines with Biology and Chemistry teams to advance programs.
- Functional understanding of chemical principles and structure-activity relationships.
- Experience in complex sample preparation including immunoprecipitations, small-molecule enrichments, and whole proteome analysis.
- Knowledge in biophysical characterization methods for proteins (SDS-PAGE, Western blot) and an interest in advanced methods (NanoBRET, SPR, ITC, etc.) is a plus.
- Well-rounded molecular biology toolkit including: CRISPR, transient transfection, generating stable cell lines, mutagenesis, etc.
- Tissue culture experience with immortalized cell lines (suspension and adherent). Primary tissue culture experience is a plus.
- General understanding of proteomic acquisition and quantitative analysis techniques and experience with different data analysis platforms is advantageous such as IP2, MaxQuant, Skyline, and Proteome Discover.
- Familiarity with target deconvolution approaches including chemoproteomics, CESTA, DARTS and FUSION.
- Working knowledge of cell biology and high-throughput screening techniques.
WHAT YOU’LL BRING TO THE TEAM
- People-first approach. You take pride in the way you collaborate and partner with people across the business.
- Passion for problem solving. You are excited by new challenges and know how to achieve maximum results and drive projects forward.
- Thirst for overachieving. You don’t just meet goals, you set the standard.
- Candidate must have excellent problem-solving skills and be self-motivated.
- Strong ability to communicate with project teams through presentations and preparation of data packages.
- Clearly and accurately document work.
- Perform under tight timelines and work effectively across multiple projects and align with different project teams.
WHAT YOU’LL GET AS PART OF OUR TEAM
- A collaborative, fun, and positive culture.
- Limitless growth and learning opportunities.
- A chance to make a lasting impact on drug discovery and human health.
- Competitive compensation and company ownership.
- Excellent Medical, Dental and Vision coverage from a broad choice of providers and plans.
- 100% of Target premium coverage for employees; 85% of Target premium coverage for eligible dependents
- 401(k) program with a company sponsored contribution.
- “Take what you need” vacation and sick leave policy.
- 10 annual paid company holidays, plus the last week of December.
- A new office and lab space in San Diego with flexibility and autonomy to do your work how and where you need.
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Belharra Therapeutics, Inc.