Principal Scientist, Modeling & Simulation RLT
Job ID: REQ-10019028
Date: Sep 03, 2024
Location: USA
Summary
Principal Scientist I/II, Radioligand Modeling & Simulation. This position will be located in Cambridge, MA and will not have the ability to be located remotely.
About the Role
We are seeking a translational or clinical modeler eager to accelerate radioligand discovery & development by facilitating rigorous decision making with modeling & simulation. You will work in a multi-disciplinary environment, with opportunities to engage in cross-functional initiatives. This role reports to a PK Sciences Translational Modeling team lead, in a group situated within Biomedical Research, the research engine of Novartis.
Key Responsibilities:
- Act as the Translational M&S representative on radioligand therapy programs, developing and executing modeling strategies, contributing to project team discussions, and guiding therapeutic design and dose selection decisions.
- Build and apply innovative QSP and physiologically based PK (PBPK) models along with dosimetry estimations to link RLT pharmacology, tissue biodistribution, mechanism(s) of action, and biological and clinical outcomes.
- Contribute to an integrated RLT modeling platform that bridges data and knowledge across preclinical species and patients, partnering with discovery project teams as well as the preclinical safety and pharmacometrics groups.
- Implement innovative quantitative approaches to advance the translational science for radiopharmaceuticals.
- Proactively seek opportunities to increase the impact and awareness of translational and clinical modeling through communications with internal and external audiences.
- Ph.D. in biology, pharmaceutical sciences, bioengineering, biophysics, or a related field along with demonstrated expertise in radiobiology / nuclear medicine. To be considered at the Principal Scientist II level must have 2-3 years plus related experience ideally in industry.
- Prior experience in pharmacokinetics and pharmacodynamics (PK/PD), quantitative systems pharmacology (QSP), and/or physiologically based PK (PBPK) modeling is preferred.
- Expert level proficiency in core modeling fundamentals is required, including scripting languages (e.g., MATLAB, R), construction of ordinary differential equation (ODE) models, parameter estimation, and data visualization.
- Demonstrated ability to communicate modeling results to a multidisciplinary audience to facilitate decision-making.
- To be considered as a Principal Scientist II must have demonstrated ability and experience leading modeling projects with drug discovery/development project teams, generating innovative ideas and objectives within a team, and coaching/mentoring junior modelers.
- Fluent in English (oral and written).
This is a dual level posting. The final level and title of the offer role would be determined by the hiring team based on the skills, experience & capabilities required to perform the role at the level the role has been offered.
Benefits and Rewards:
Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: Novartis Life Handbook.
Commitment to Diversity and Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.
The Novartis Group of Companies are Equal Opportunity Employers who are focused on building and advancing a culture of inclusion that values and celebrates individual differences, uniqueness, backgrounds, and perspectives.
Accessibility & Reasonable Accommodations
The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
Division: Biomedical Research
Business Unit: Pharma Research
Location: USA
Site: Cambridge (USA)
Company / Legal Entity: U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.
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