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Job Description
About the role:
At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.
Join Takeda as a Research Scientist, Cell Engager Therapies In Vivo Pharmacologist where you will be responsible for the discovery and development of novel therapeutics in the T cell engager space supporting new and ongoing pipeline programs. This is a fully lab-based role where you will work with the in-vivo lead and and be responsible for critical path activities. You will be asked to have a strong foundation in in vivo models of cancer. As a key member of the team, you will be responsible for new in vivo model development, target validation, assessing therapeutic concepts of various immune engager molecules and advancing development candidates to IND. You will collaborate and demonstrate effective communication and documentation of results. As part of the Oncology Drug Discovery Unit, you will report to Associate Director In Vivo Lead Cell Engager Therapies.
How you will contribute:
Development of animal models to test the biological efficacy of therapeutic agents for oncology indications.
Design and execute in vivo efficacy models in xenograft and PDX models.
Participate in analysis of in vivo studies to help establish PK / PD / efficacy relationships.
Execute experiments with minimum supervision and deliver comprehensive high quality data sets to enable decision making.
Ability to multi-task effectively and prioritize workload.
Interpret results of complex experiments.
Prepares and presents comprehensive technical or project reports and formal presentations.
Maintain laboratory notebooks and follow laboratory practices in compliance.
Demonstrate in-depth technical in vivo knowledge.
Clarify requests and provide suggestions and put data into context especially in context of study design and quality of data.
Be a in vivo SME on projects providing scientific feedback to advance programs in a matrixed environment.
Provide information to project teams to influence direction, align with departmental goals and/or business.
Conduct scientific presentations to internal audiences.
Collaborate with others across sites, and act as scientific resource for in vitro pharmacology.
Strive towards expanding scientific knowledge in immunology.
Receive high level instructions on work; determine methods on new assignments; demonstrated greater independence; may manage interns.
Minimum Requirements/Qualifications:
MS with 4+ years' experience, or BS with 6+ years' of research experience in lab setting working with animals.
Experience in industry required, in animal facilities.
Proficiency with in vivo efficacy rodent models, including mouse syngeneic, xenograft and PDX models.
Experimental skills, including mammalian tissue culture, in vivo model development, drug administration by multiple routes (IV, SQ, IP, PO, RO), and blood/tissue collection. Imaging experience is highly desirable.
Experience culturing and maintaining human tumor cell lines and primary human cells, preferably T cells, with best practices in tissue culture is critical.
Hands –on basic experience with multi-color flow cytometry, ELISA, MSD and other standard cell based and non-cell based biochemical assays is desired.
Use of scientific databases and application for data management and data analysis (Graph Pad Prism, Soft Max Pro, Office 365, FlowJo etc).
Excellent team player with a can-do attitude with an ability to thrive in a dynamic "biotech- like" environment and work in cross-functional project teams.
Self-motivated, collaborative with excellent time management and organizational skills.
Takeda's high-engagement culture is an important factor in our success; we seek team members who will contribute to and further strengthen that culture.
More about us:
At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.
Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
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Takeda Compensation and Benefits Summary
We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
For Location:
Boston, MAU.S. Base Salary Range:
$108,500.00 - $170,500.00The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained , certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.
U.S. based employee s may be eligible for s hort - t erm and/ or l ong- t erm incentive s . U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.
EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.