Computational Chemist I

Computation is revolutionizing drug discovery. Advances in big chemical data, massive computing power, artificial intelligence, and molecular dynamics simulation are changing the way we develop new drugs. At 1910 Genetics, we put computation at the heart of drug discovery, blending expertise in computational chemistry, structural biology, pharmacology, genetics, data science, and software engineering to develop drugs for previously undruggable targets.

You are someone we can count on to...

• Roll up your sleeves as an Individual Contributor (IC) and play an important role in our mission to use AI/ML to develop drugs against historically difficult disease targets.

You will own…

• Computational chemistry programs across therapeutic modalities, disease targets, and indications.
• Implementation of computational chemistry toolkits (e.g., MOE, CCDC, Cresset) to run virtual screening campaigns to rapidly identify drug candidates for further development while proactively seeking and incorporating input from Medicinal Chemistry.
• Effective collaboration with the Biology and Medicinal Chemistry teams by providing key computational chemistry insights to aid in the Hit-to-Lead and Lead Optimization phases of drug discovery operations.
• Effective collaboration with the ML Engineering and AI Research team by providing key computational chemistry insights to aid in the development of AI/ML models for drug discovery as well as the incorporation of those models into drug discovery operations.

You will learn...

• Medicinal Chemistry.
• Biochemistry and biophysics.
• AI/ML applied to drug discovery.
• Existing tools, systems, and processes that currently support the 1910 Genetics team.

You will teach...

• Key computational chemistry principles to your cross-disciplinary colleagues from Medicinal Chemistry, AI Research, Machine Learning Engineering, Cell Biology, and Pharmacology.

You will improve…

• Our existing process for progressing from computational hit to experimental hit to lead to drug candidate.

Within 1 month you will…

• Propose a few hundred virtual hits to the Medicinal Chemists for synthesis.

Within 3 months you will…

• Progress a virtual hit to a biochemical/cellular hit.
• Co-author provisional patents on hit scaffolds.

Within 6 months you will…

• Validate a cellular hit in a clinically relevant animal model of disease.
• Update provisional patents with the animal model data.

Within 12 months you will…

• Nominate a lead candidate for progression into IND-enabling studies.

Ideally, you have…

• Ph.D. in chemistry.
• 2+ years of postdoctoral or industrial experience.
• Proficiency with the Microsoft Office Suite (Excel, Word, PowerPoint, Teams), G-Suite.
• Extremely generous equity package coupled with competitive salary.