Senior Associate Scientist I or II, Biology
Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services, and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
RayzeBio is a dynamic biotechnology company headquartered in San Diego, CA. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio will operate as a standalone entity within the BMS organization, maintaining its biotech culture with the opportunity to leverage the best-in-class oncology capabilities of BMS. RayzeBio is developing innovative drugs against targets of solid tumors. The lead asset, RYZ101, is in Phase 3 testing for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs), as well as earlier stage testing for patients with small cell lung cancer (SCLC). Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.
*This is an onsite position located at Rayzebio's San Diego, CA office
Key Responsibilities:
- Develop and optimize SPR and biosensor-based assays for the evaluation of biomolecular interactions, particularly in the context of oncology targets to support the screening, characterization, and lead-identification of novel RPT agents.
- Conduct routine screening experiments using SPR and biosensor platforms to generate high-quality data for project teams.
- Operate and maintain SPR and biosensor instruments, ensuring optimal performance and troubleshooting technical issues as needed.
- Generate, organize, and maintain meticulous records on all conducted experiments. Independently analyze and interpret data and present experimental plans and results at project team meetings, group meetings, and company meetings.
- Actively contribute to the experimental design and planning efforts to help achieve project goals under tight timelines.
- Work with radioactivity in various assays in strict adherence to the radiation safety protocols.
- Work under the guidance of project team leaders to support the overall biology screening and evaluation plan, work closely with chemists, DMPK, imaging and in vivo teams to ensure implementation of screening funnel and appropriate prioritization of experiments.
- Collaborate with colleagues in other functional areas including translational research and chemistry.
- Assist in laboratory operation management duties.
Education and Experience:
- BS with 4+ years of experience or MS 2+ years of experience within Biology, Biochemistry, Molecular Biology, or a related discipline with hands-on laboratory experience.
- Proven experience in SPR and biosensor assay development and operation, ideally within the oncology field.
- Hands-on expertise with SPR instruments (e.g., Biacore 8k, ProteOn) and biosensor technologies (e.g., BLI, SPRi).
- Prior experience of working on drug discovery projects in an industrial or an academic setting is preferred.
Skills:
- Demonstrated expertise in the experimental design, running and data analysis of various SPR methodologies.
- Proficient with a variety of ligand immobilization techniques, ligand regeneration conditions, and execution of epitope binning experiments.
- Familiarity and hands-on experience with in vitro, cell-based assay development and optimization and proficiency with cell culture, molecular biology techniques, ELISA, flow-cytometry, western blot, qPCR, single-cell cloning, immunohistochemistry and related protocols is a plus.
- Excellent written and oral communication and presentation skills and ability to work in a fast-paced, dynamic, and collaborative environment.
- Strong interpersonal, organizational and communication skills.
- Familiarity with drug development process and interfacing and working with interdisciplinary teams.
- Ability to work with radioisotopes with strict adherence to radiation safety protocols.
The starting compensation for this job is a range from $92,601-$125,285, plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience.
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If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.