Job Title:
Scientist/Senior Scientist
Location:
San Diego, CA
Position type:
Full time
FLSA:
Exempt
Department:
Biology
Strive to Bring a Profound Difference to our Patients
At Avidity Biosciences, we are passionate about the impact of every employee in realizing our vision of improving people’s lives by delivering a new class of RNA therapeutics. Avidity is revolutionizing the field of RNA with its proprietary AOCs, designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies. If you are a committed, solution-oriented thinker, join us in making a difference and become part of our growing culture that is integrated, collaborative, agile and focused on the needs of patients.
Avidity Biosciences, Inc.'s mission is to profoundly improve people's lives by delivering a new class of RNA therapeutics - Antibody Oligonucleotide Conjugates (AOCs). Utilizing its proprietary AOC platform, Avidity demonstrated the first-ever successful targeted delivery of RNA into muscle and is leading the field with clinical development programs for three rare muscle diseases: myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). Avidity is broadening the reach of AOCs with its advancing and expanding pipeline, including programs in cardiology and immunology through internal discovery efforts and key partnerships. Avidity is headquartered in San Diego, CA. For more information about our AOC platform, clinical development pipeline, and people, please visit and engage with us on LinkedIn and Twitter .
The Opportunity
Avidity Biosciences is seeking an innovative in vivo Scientist that will be a key member of the scientific team that shapes a culture of intellectual rigor and collegiality at Avidity. This scientist will be leading the discovery and development of AOCs for treatment of cardiac diseases. We are looking for a scientist who brings enthusiasm, curiosity, scientific rigor, and a desire to innovate new medicines for patients. This position will work cross-functionally with clinical development, legal, finance, regulatory affairs, and business development, as needed.
What You Will Contribute
- Provide expertise and leadership for rodent models of heart disease to evaluate potential clinical candidates and address key biology questions.
- Lead and execute the evaluation and selection of lead siRNA molecules in vivo, using Avidity’s AOC technology.
- Generate critical data to advance projects forward and deliver candidates for clinical development.
- Professionally represent the organization externally in collaborations and conferences.
- Develop strong relationships and communicate effectively with the executive staff, other members of the biology group, and academic collaborators.
- Supervising and mentoring Research Associates.
What We Seek
- Ph.D. in life sciences with 3+ years of post-doctoral or biotech/biopharma experience.
- Demonstrated expertise in cardiac and or skeletal muscle biology.
- Demonstrated experience with mouse models of heart disease and evaluation of cardiac function using ECHO and ECG.
- Isolation and culture of primary cardiomyocytes is a plus.
- Experience with in vitro disease models using primary human cells to support drug discovery is desirable.
- Experience with large molecule (monoclonal antibody) and/or oligonucleotide based therapeutic modalities in drug discovery and development is desired but not required.
- Excellent interpersonal skills, ability to work in a matrix environment and develop relationships with key stakeholders.
- Excellent communication and presentation skills to efficiently relay information to project teams, senior management teams, and other key stakeholders.
- Proven ability to work independently, think strategically and be self-motivated.
What We Will Provide to You:
- The base salary range for this role is $110,000 - $164,000. The final compensation will be commensurate with such factors as relevant experience, skillset, internal equity and market factors.
- Avidity offers competitive compensation and benefits which includes the opportunity for annual and spot bonuses, stock options and RSUs, as well as a 401(k) with an employer match. In addition, the comprehensive wellness program includes coverage for medical, dental, vision, and LTD, and four weeks of time off.
- A commitment to learning and development, which includes a variety of programming internally developed by and for Avidity employees, opportunities for job-specific training offered by industry, and an education reimbursement program.