Modeling & Simulations Senior Scientist

Job Description

General Summary:
The Modeling & Simulations Senior Scientist at Vertex will lead Modeling & Simulation analyses from planning through reporting and align these analyses with the strategy determined by the modeling program lead. Types of analyses can include modeling and simulation to support evaluation of study design, dose selection, probability of success estimation, portfolio strategy, pediatric extrapolation, etc. It is expected that this role will work in close collaboration with colleagues in Clinical Pharmacology, Biostatistics, Research, and other colleagues within the R&D organization.

Key Duties and Responsibilities:

1. Development and execution of Modeling & Simulation plans and analyses fully integrated with the overall development plans.
2. By using state-of-the-art Modeling & Simulation methodologies, strongly contribute to critical decision making like study design, dose selection, probability of success estimation, etc.
3. Contribute to the continuous improvement in efficiency and effectiveness of our M&S capability by supporting training activities, evaluating and incorporating new M&S tools as appropriate.
4. Perform mechanism-based PKPD and population PK and PK/PD analyses, clinical trial simulations, translational modeling (preclinical – clinical) and other model-based analyses in collaboration with other scientists on a regular basis.
5. Contribute M&S expertise to multiple projects, including as the lead representative for specific analyses and evaluate and interpret analysis results.
6. Organizes and participates in departmental functions and represents the department in company-wide, non-scientific initiatives.
7. Integrate modeling into decision making by clearly communicating key results.

Knowledge and Skills:

1. Strong experience working in clinical development teams and integrating the use of PK/PD modeling and/or modeling of complex biological systems.
2. A deep understanding of biology, pharmacokinetic and quantitative pharmacology (PKPD) principles.
3. In-depth hands-on skills in population PK and PKPD modeling, mechanistic PKPD modeling, Clinical trial simulations, Disease progression modeling, etc.
4. Advanced skills in the use of NonMem, PsN, R, Phoenix, and similar tools.
5. Excellent verbal and written communication skills.

Education and Experience:

1. Master's or PhD, with preference in Pharmaceutical sciences, Pharmacometrics, mathematics, statistics, or other quantitative discipline with an emphasis on Pharmacometrics and PKPD modeling.
2. Typically requires the following: PhD and 3 years experience or Master's Degree and 6 years experience in the application of Pharmacometric and other Modeling methodologies in the context of drug research & development in industry, academia or regulatory agencies.

Pay Range:

$142,400 - $213,600 USD annually

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

Flex Designation:

Remote-Eligible

Company Information:

Vertex is a global biotechnology company that invests in scientific innovation.