About this position:
We are seeking a highly talented and motivated Scientist with expertise in Biomolecular Simulations to join our team in San Diego to advance Neomorph’s small-molecule drug discovery programs. As part of a multi-disciplinary team comprising of leaders in the field of targeted protein degradation, the suitable candidate will develop, implement and apply advanced physics-based and AI/ML computational methods to establish novel approaches for Drug Discovery and selection of therapeutic targets. This is a highly collaborative position that will focus on understanding the mechanistic details of small molecule mediated protein-protein interactions to enable the discovery of novel, more efficient, and selective degraders.
Job responsibilities:
- Develop computational tools to predict small-molecule changes in protein-protein interactions and apply it to prioritize targets of interest.
- Identify and apply novel methods to predict dynamic ligandable sites.
- Use internal data such as affinity and protein degradation to develop, validate, and deploy high-accuracy scoring functions of ligand-PPI using Binding Free Energy and AI/ML methods.
- Implement and integrate high-throughput physics-based methods such as docking, molecular dynamics, free energy as well as AI/ML approaches to enable an efficient structure-based drug design environment.
- Collaborate with medicinal chemists to translate computational predictions into ligand designs and compound prioritization.
- Collaborate effectively within cross-functional teams, providing computational insights and expertise to support project goals and timelines.
- Stay up-to-date with the latest advancements in molecular dynamics, protein degradation, and drug discovery fields, and proactively apply new techniques and methodologies to improve project outcomes.
- Contribute to scientific publications, patents, and presentations to communicate research findings and contribute to the intellectual property portfolio of the company.
Required Qualifications:
- Ph.D. in Computational Chemistry, Computational Biology, Computational Biophysics or related field with 2+ years of relevant industry experience.
- Knowledge and expertise in the use of molecular dynamics, enhanced sampling methods and free energy approaches applied to drug design.
- Background in the computational prediction of protein-protein interaction.
- Experience with molecular dynamics software such as AMBER, GROMACS, OpenMM and NAMD.
- Robust coding experience using modern scientific languages (Python/C++/etc.).
- Experience with Python API to analyze protein dynamics and protein-ligand interaction, i.e., (MDTraj, MDAnalysis, and Schrodinger Python API).
- Mastery of Linux OS and command-lines.
- Experience in distributed computing using HPC clusters or cloud platforms.
Preferred Qualifications:
- Ability to communicate, collaborate, and deliver results as a member of multi-disciplinary teams.
- Basic knowledge of medicinal chemistry principles.
- Experience with commercial computational chemistry packages such as Schrodinger, Openeye or others is a plus.
- Experience with LLM protein structure prediction methods.
- Physical chemistry background and knowledge of organic chemistry.
- Experience with computational approaches to fragment-based ligand design or DNA-encoded libraries.
What we offer:
- Industry competitive compensation.
- Annual target bonus.
- Stock options.
- 401K plan.
- Career advancement opportunities.
- Monthly town halls to share business and scientific updates.
Work Hard, Stay Well
- Comprehensive medical, dental, and vision plans for employees and their dependents.
- Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution.
- Employee Assistance Program.
- 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
- Supplemental pay for Pregnancy Disability Leave.
- Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care.
Lifestyle
- Casual work environment.
- Volunteer days off each year to spend time contributing to causes you care about.
- Flexible work schedule.
- Access to an onsite gym.
- Onsite space to store your bicycle (or surfboard).
Have Fun!
We believe in work/life balance, and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (e.g., Padres games, summer picnic, holiday party, bring your kids to work day).
About Us:
Neomorph is a venture-backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets’. Our team is comprised of industry-leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment.
Neomorph is headquartered in San Diego, California, and has a key collaboration with the Center for Protein Degradation at the Dana-Farber Cancer Institute.
Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal-opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state, or local law.
#J-18808-Ljbffr