Principal Scientist

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Eli Lilly and Company seeks a Principal Scientist to formulate and characterize novel nucleic acid delivery constructs. Responsibilities include:

1. Evaluate nucleic acid delivery constructs and optimize related protocols.
2. Troubleshoot experimental issues and visualize, summarize, and present results to team members.
3. Apply a systematic and rigorous approach to scientific research and collaborate with a multidisciplinary team.
4. Provide formal and informal mentorship and training to junior colleagues.

Minimum Requirements:

Position requires a Bachelor’s degree in Pharmaceutical Sciences, Biotechnology, Chemical Engineering or a related field and 3 years of academic or employment experience with evaluation and characterization techniques from cell and tissue samples. Academic or employment experience must include:

1. 2 years of experience with in vitro characterization techniques e.g., cell culture, and cell transfection;
2. 1 year of experience with in vitro/vivo endpoint analysis e.g., ELISA, and qPCR;
3. 1 year of experience with immunohistochemistry;
4. 1 year of experience with in vivo techniques, tissue collection and molecular endpoints on tissue samples;
5. 6 months of experience with the formulation and analytical characterization of nucleic acids and nucleic acid-loaded nanoparticles;
6. 6 months of experience with DLS, SEC, and Ribogreen;
7. 6 months of experience with optimization of protocols for formulation of nucleic acid delivery constructs;
8. 6 months of experience on nucleic acid constructs.

Part-time telecommuting may be permitted.

Job location: Cambridge, MA. To apply, please visit and enter job requisition number R-69903 when prompted. Alternatively, please send your resume, cover letter, and a copy of the ad to: Beth L. Berry, Lilly Corporate Center, Indianapolis, IN 46285.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to helping individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note this email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

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