Associate Director / Director, Protein Sciences

• Company Address: 828 Winter St, Waltham, Massachusetts 02451, US

About Xilio Therapeutics

Focused on harnessing the immune system to achieve deep and durable clinical responses to improve the lives of patients.

Job Description

Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company is using its proprietary platform to advance a pipeline of novel, tumor-activated clinical and preclinical I-O molecules that are designed to optimize their therapeutic index by localizing anti-tumor activity within the tumor microenvironment, including tumor-activated cytokines and antibodies (including bispecifics) and immune cell engagers (including tumor-activated cell engagers and tumor-activated effector-enhanced cell engagers). Learn more by visiting and follow us on LinkedIn (Xilio Therapeutics, Inc.).

SUMMARY:

We are looking for an energetic and motivated Director for our Protein Science Team that will be responsible for mammalian expression and purification of therapeutic candidate molecules. This is a high-impact role at the center of translating design concepts into physical form. As such, the Director will have wide-ranging responsibilities at the interface of protein engineering, protein science, biology and CMC to lead as part of a dynamic, enthusiastic, highly interdisciplinary and collaborative team.

Job Responsibilities:

• Manage a team of scientists in protein production, purification and platform development to help deliver therapeutic candidates to the pipeline within agreed-upon timelines.
• Provide technical, operational and strategic input on all matters relating to the discovery and production of therapeutic candidates and their advancement in Xilio’s pipeline.
• Represent Protein Science group as project team representative and coordinate resource allocation in alignment with the Research Leadership Team.
• Facilitate efficient advancement of therapeutic candidates through the pipeline by serving as a conduit at the interface of protein engineering, protein science, biology and CMC and effectively collaborating cross-functionally.
• Proactively assess different technologies, methods, and emerging tools to increase operational efficiency and establish the PS group as a center of scientific excellence.
• Work with CROs, collaborators and partners to transfer samples, data and protocols into, or out of, Xilio, as appropriate.

Skills, Qualifications, and Requirements:

• Ph.D. in Biochemistry or a relevant scientific discipline + 7-10 years of industry experience, or MS + 10-12 years of therapeutic protein expression and purification.
• Experience with leading a committed team of protein scientists and communicating timelines and priorities.
• Experience in protein expression of multiple molecule types, including antibodies, fusion proteins, and bispecific proteins from mammalian cell lines, including HEK293 and CHO transient and stable expression platforms is required.
• Strong technical expertise with AKTA-based protein purification with various chromatography techniques, including affinity, ion exchange, SEC, HIC, etc.
• Experience with common protein characterization methods, including SDS-PAGE, HPLC, CE-SDS, MALS, and endotoxin.
• Experience with developability/manufacturability assessments including a range of biophysical methods desired.
• Experience with robotics, high throughput expression and purification platforms and bioanalytical characterization techniques is highly desirable.
• A track record of innovation and scientific rigor, strong problem solving and troubleshooting skills, and ability to contribute constructively to discussions.
• Goal oriented, organized, capable of prioritizing and working on multiple projects, and able to execute timelines that meet company goals.
• Work well in a cross functional team environment, both independently as well as be willing to help others.
• Excellent verbal and written communication skills.

Diversity, Equity and Inclusion

At Xilio Therapeutics, we foster a culture of equity, diversity and inclusion. We consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law. We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability who requires accommodation with the hiring process or to perform any essential functions of the position for which you are applying, please reach out to .