Principal Scientist, Chemical Development

Description:

Job title: Principal Scientist, Chemical Development

Company : Immunome, Inc.

Location : Bothell, Washington

Company Overview

Immunome is a biotechnology company dedicated to developing first-in-class and best-in-class targeted cancer therapies. Our portfolio pursues each target with a modality appropriate to its biology, including small molecules, ADCs, and RLTs. We believe that pursuing underexplored targets with appropriate drug modalities leads to transformative therapies. Our proprietary memory B cell hybridoma technology allows for the rapid screening and functional characterization of novel antibodies and targets

Position Overview

We are seeking an experienced process development chemist (Principal Scientist level) to join our dynamic team to help advance our pipeline of innovative targeted cancer therapies. The successful candidate will bring expertise in small molecule process development and manufacturing. The candidate will apply their chemical development expertise to a variety of modalities in the Immunome pipeline including antibody drug conjugates and radiopharmaceuticals. This person will play a key role in leading challenging drug candidate process development programs thus enabling treatment of patients in need.

Key Responsibilities

Leadership:

• Provide technical leadership as a key member of the chemical development team while maintaining alignment with the company's goals and objectives.
• Function as the technical lead on at least one program while also functioning as an individual technical contributor.
• Provide guidance and leadership to external partners working towards the successful advancement of antibody drug conjugates, radiopharmaceuticals, and other lead programs.
• Support programs at the bench as an individual contributor as needed.

Technical expertise :

• Leverage knowledge and experience in the development and execution of robust and scalable small molecule synthetic processes.
• Devise and evaluate alternative routes of synthesis with the aim of developing robust and efficient routes to API’s while reducing cost of goods (COG’s) and shortening manufacturing lead times.
• Develop robust data packages for technical transfer of processes for manufacturing partners at external CMO’s.
• Maintain knowledge of the current state of the art in synthetic methods utilized for the construction of complex molecules.
• Carry out thorough analytical data collection both as an individual contributor in the lab as well as via oversight and review of data collected at our external partners.
• Contribute to authoring relevant sections of various regulatory documents (IND, IMPD, NDA, briefing books, etc.) and provide SME support for related regulatory inquiries.

Cross-functional Collaboration :

• Execute the integrated CMC regulatory strategies for pipeline programs.
• Collaborate with research, regulatory affairs, and CMC teams to ensure seamless coordination of activities.
• Foster strong collaborations with internal and external stakeholders.
• Engage colleagues in discovery chemistry to provide CMC input of target molecules under evaluation for future development.

Innovation:

• Stay abreast of the latest advancements in synthetic methodology as well as new technologies and methodologies to enhance our capabilities.
• Advances Immunome’s intellectual property portfolio.

Quality and Compliance :

• Ensure compliance with relevant regulatory guidelines and industry standards for chemical development processes.
• Uphold high-quality standards and address any compliance issues.

Educational Background : Ph.D. in Synthetic Organic Chemistry or other related field.

Professional Experience : Minimum of 8 years of industry experience leading small molecule, antibody drug conjugates, radiopharmaceuticals programs. Experience as a technical lead overseeing tech transfer, process development and implementation of processes for manufacture at internal and/or external manufacturers is a plus.

Knowledge and Skills:

• Ability to design cost effective robust manufacturing processes for complex small molecule targets as well as troubleshoot and solve complex technical challenges quickly.
• Brings a collaborative and open-minded attitude when working with various internal and external teammates.
• Meticulous and detail-oriented scientist with the ability to operate as an individual contributor at the bench while also managing external partners.
• Proficient in generating robust and reliable analytical data utilizing various technologies in a hands on capacity as well as evaluation of analytical data generated at external partners.
• Proficient in writing technical reports and formulating presentations
• Ability to develop cross functional relationships with discovery chemistry and other pre-clinical groups.
• Experience in leading and managing technology transfers to third party process development and manufacturing partners.
• Knowledge of cGMP requirements and ICH guidelines related to CMC small molecule drug-substance development and manufacturing.
• Track record of working closely with cross-functional teams in a biopharmaceutical or pharmaceutical environment.
• Excellent interpersonal and communication skills.
• Track record of innovation in the development of chemical processes.
• Ability to solve complex scientific problems and make data-driven decisions.

Position may require domestic and international travel (between 5 to 15%)

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

Salary Range

$157,000 - $177,000