What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform human health and sustainability?
Flagship Pioneering's venture creation engine has conceived and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Sana Biotechnology (NASDAQ: SANA), Generate Biomedicines, and Tessera Therapeutics. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $212 billion in aggregate value.
The Company:
Quotient Therapeutics, Inc. is a privately held, early-stage company developing a novel genomics platform and therapeutics for diseases with a large unmet need.
Position Summary:
We are seeking an accomplished Principal Scientist to join our drug discovery team as protein engineering / antibody discovery lead. The successful candidate will spearhead the design, development, and optimization of biologic therapeutics, with a focus on advancing innovative treatments from discovery through preclinical development.
Key Responsibilities:
- Antibody screening and discovery: design, develop and implement strategies for discovery of various antibody formats. Utilize advanced technologies to identify high-affinity antibodies.
- Molecular engineering and characterization: Perform antibody engineering and characterize binding affinity, specificity and epitope mapping using relevant techniques.
- Assay Development: Contribute to the development and implementation of high-throughput screening assays and other in vitro and in vivo models to evaluate the efficacy, safety, and mechanism of action of biologic candidates.
- Project Oversight: Lead cross-functional project teams to design, plan, and execute experimental studies, ensuring milestones and objectives are met within established timelines.
- Data Analysis and Interpretation: Utilize advanced analytical techniques and tools to interpret complex datasets, and drive data-driven decision-making.
- Collaboration and Communication: Collaborate with internal and external stakeholders, including research scientists, engineers, translational teams, and KOLs to advance biologics projects.
Qualifications:
- Educational Background: Ph.D. in Molecular Biology, Immunology, Biochemistry, or a related discipline, with at least 8-10 years of experience in biologics research within the biotech or pharmaceutical industry.
- Subject Matter Expertise: Comprehensive knowledge of biologic drug discovery and development processes, including target validation, lead optimization, and preclinical evaluation.
- Technical Skills: Proficiency in molecular and cellular biology techniques, protein engineering, expression, purification, and characterization methods.
- Leadership Experience: Demonstrated experience leading project teams and managing scientific personnel.
- Communication Skills: Outstanding written and oral presentation skills.
- Personal Attributes: Highly motivated, results-oriented, and team-focused individual with a strong commitment to advancing innovative therapies.
Preferred Attributes:
- Technical expertise: Experience in computational biology or bioinformatics related to antibody design.
- Regulatory Knowledge: Familiarity with regulatory requirements and guidelines for biologic therapeutics.
Location: Cambridge, MA
About Flagship:
Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability.
Equal Employment Opportunity: Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way.
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